Advantix II – Frontline Plus Comparison Chart

Comparing flea control treatments can be overwhelming; here is a comparison chart to help clear things up. Both K9 Advantix and Frontline Plus kill and prevent fleas and ticks very effectively, but sometimes there are other factors you should consider when choosing between the two.

 K9 Advantix IIFrontline Plus
Kills FleasYesYes
Repels FleasYes
Kills TicksYesYes
Repels TicksYes
Kills Flea Eggs & LarvaeYesYes
Kills LiceYesYes
Repels & Kills MosquitoesYes
Repels Biting Flies & Stable FliesYes
Repels & Kills Sand FliesYes
Lowest Price This Week



As you can see, K9 Advantix II is formulated to provide a more complete solution for killing and repelling parasites and pests. If you live in an area where fleas or ticks are the main problem, and you don’t have issues with flying insects and biting insects then Frontline Plus is more than sufficient. However, if you do live in an area that has a wide variety of pests for part of the year or year-round, then K9 Advantix may be a better solution. See our full comparison article, Advantix vs Frontline for more details.

In regards to pricing, I have found that among the larger pet meds sellers online K9 Advantix II pricing tends to be almost the same on all sites. I check prices every month and the lowest price is consistently on here at PETCO.

It’s easier to get Frontline Plus cheap. Frontline Plus seems to have a much larger distribution market than K9 Advantix II and the competition factor has driven the prices way down. Here is my recommendation for getting Frontline Plus on the cheap.

When I buy Frontline Plus for my three dogs I like to buy in bulk to save more $$.

Since I have three dogs, a twelve month supply of Frontline Plus lasts me four months so I typically buy a twelve month supply every four months. It’s always best to buy your Frontline in the largest pack you can afford at the time you are buying. The larger packs are significantly cheaper than if you decided to buy a three pack every three months. If you just order the small packs, with many pet meds sellers you won’t qualify for free shipping. So if you are ordering a few times per year, the shipping costs add up.

If you order the 12 pack you end up saving the most money because you only have to order once or twice per year and the discount price of the 12 pack absorbs the shipping cost (if there is one). A 12 pack order of Frontline Plus will qualify you for free shipping with almost any pet meds merchant.

There is another good place to buy both Frontline Plus and K9 Advantix II, I don’t personally buy from this source but I know some of my friends like to get their pet meds there. You can get a lot of different flea control products on There are some good deals sometimes, but just be sure to read the reviews on any seller you are considering because I have seen a lot of “unknowns” selling flea control products on Amazon. That being said, you can find good deals there from reputable sellers.

In Summary

In our chart we covered the similarities and differences between these two “top of the line” flea and tick medications. You really can’t go wrong with either of these flea meds, I have used both and can attest to their effectiveness. Your choice really depends upon you and your pet’s circumstances, environment, budget, etc.

I also gave you my best sources for purchasing either of these medications. If you find these meds at a cheaper price somewhere, please let me know! The purpose of this site is to help inform fellow pet owners about these products and also show them where to buy them at the best prices. So if you can think of any way I can improve my chart, please feel free to contact me with your suggestions.

I hope the comparison chart has helped you on your way to deciding which flea med is better for your pet. Subscribe to updates and stay tuned for new comparisons, discounts, and more.

Advantix Vs Frontline Comparison Chart